[tex]8^{16} : \Big(2 \times 2^4 \times 2^{10}\Big)^3 - 2^1- 2^0= \\ \\
=8^{16} :\Big(2^{1+4+10}\Big)^3 - 2^1- 2^0= \\ \\
=\Big(2^3\Big)^{16} : \Big(2^{15}\Big)^3 - 2^1- 2^0= \\ \\
=2^{3 \times16}:2^{15\times 3} - 2^1- 2^0= \\ \\
=2^{48}: 2^{45} - 2^1- 2^0= \\ \\
=2^{48-45} - 2^1- 2^0= \\ \\
=2^3 - 2^1- 2^0= 8 - 2 - 1 =6 - 1 = \boxed{5}[/tex]